Relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with ADHD

نویسندگان

  • James Lee
  • Natalie Grizenko
  • Venkataramana Bhat
  • Sarojini Sengupta
  • Anna Polotskaia
  • Ridha Joober
چکیده

BACKGROUND The desired (therapeutic) and undesired (side) effects of methylphenidate might have underlying correlations. The aim of this study was to explore the strength and the possible sources of these correlations. METHODS One hundred and fifty-seven children with ADHD (6-12 years) were administered placebo and methylphenidate (0.5 mg/kg in a divided b.i.d. dose), each for a one-week period, in a double-blind, crossover trial. Therapeutic response was assessed using the Conners' Global Index for parents (CGI-Parents) and teachers (CGI-Teachers), while side effects were assessed using the Barkley Side Effects Rating Scale (SERS). RESULTS The side effect profile as assessed by the SERS was similar to that of previous studies with insomnia, decreased appetite, and headaches showing significant treatment effects (p < 0.005). These "somatic/physical" side effects did not correlate with CGI-Parents or CGI-Teachers. However, the side effects of "irritability", "proneness to crying", and "anxiousness" showed significant relationships with CGI-Parents. These "mood/anxiety" side effects showed no significant correlations with the CGI-Teachers. CONCLUSION The greater "mood/anxiety" side effects on methylphenidate and placebo, the less the parents observe improvement of their children while treated with methylphenidate. This suggests that the correlations between "mood/anxiety" side effects and poor response to treatment may be driven by observer effects rather than biological commonalities between therapeutic and side effects of methylphenidate.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The 5-HTTLPR polymorphism of the serotonin transporter gene and short term behavioral response to methylphenidate in children with ADHD

BACKGROUND Animal models of ADHD suggest that the paradoxical calming effect of methylphenidate on motor activity could be mediated through its action on serotonin transmission. In this study, we have investigated the relationship between the 5-HTTLPR polymorphism in the serotonin transporter gene (SLC6A4) and the response of ADHD relevant behaviors with methylphenidate treatment. METHODS Pat...

متن کامل

مقایسه اثربخشی داروی دولوکستین با متیل‌فنیدیت در درمان اختلال بیش‌فعالی کم‌توجهی کودکان

Background: Attention-deficit/hyperactivity disorder (ADHD) is a common and mostly chronic mental health condition that affects children, adolescents, and adults. Stimulants and atomoxetine are first-line agents for the treatment of ADHD. Despite the impressive track record of stimulants in the treatment of ADHD, they fail in 25% of patients due to lack of efficacy or the emergence of unwanted ...

متن کامل

Effects of Folic Acid on Appetite in Children with Attention Deficit Hyperactivity Disorder (ADHD) Treated with Methylphenidate: A Randomized Double-Blind Clinical Trial

Background: The highly effective medications in treating attention deficit hyperactivity disorder (ADHD) symptoms are stimulants like methylphenidate. However, they have adverse effects like reduced appetite. We investigated the effects of folic acid on reduced appetite caused by the use of methylphenidate in children with ADHD.Methods: This randomized double-blind clinical trial evaluated 70 o...

متن کامل

مقایسه اثربخشی بوسپیرون و متیل‌فنیدیت در کودکان و نوجوانان مبتلا به اختلال نقص توجه/ بیش‌فعالی به‌صورت متقاطع و دوسوکور

Objectives: In this study the efficacy of buspirone was compared with methylphenidate in children and adolescent with attention deficit-hyperactivity disorder (ADHD). Methods: In this randomized double blind clinical trial with crossover design, 40 children and adolescents (6-16 years old) with the diagnosis of ADHD were studied. The samples were selected by conventional method and categorized ...

متن کامل

مقایسه اثربخشی بوسپیرون و متیل‌فنیدیت در کودکان مبتلا به اختلال بیش‌فعالی کم‌توجهی

AbstractObjectives: To investigate the efficacy and side effects of buspirone in comparison with methylphenidate for controlling symptoms of children with attention deficit hyperactivity disorder (ADHD). Method: A total of thirty two 6-12 years old children with ADHD were examined. The teacher and parent ADHD Rating Scale (ADHD-RS) was used to gather data from both groups. Drug side effects wer...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2011